De Dietrich?s state-of-the-art CIP (Clean In Place) systems improve cleaning quality, reduce operating time in order to optimise reactor operations, and significantly lower solvent consumption. In addition, the repetitive cleaning cycle provides constant efficiency. CIP systems are also less labour intensive and reduce the risk of dangerous chemical exposure to workers. To meet traceability and GMP standards, pharmaceutical and chemical companies are turning to CIP systems to meet cleaning requirements.

Analytical Approach

The success of CIP technology is based on the coverage of the solvent and the internal equipment parts. The main difficulty for project managers or engineers is to ensure that the CIP system will have full coverage. De Dietrich has developed a specific approach and a high- quality process that solves the full coverage problem. With this new method, CIP component selection and optimizing is very easy. A specific numeric 

simulation is performed on the equipment to obtain the requested coverage, and the report is precise on type, number and localization of each spray-ball. This high-value simulation can be done for existing equipment or for equipment in the process of being manufactured.

On-Site Testing

To validate equipment performances, Riboflavine or Conductivity tests can be done on existing equipment in our facilities or on customer site. With this additional step, De Dietrich experts demonstrate that requested coverage is met.

The expansion of the De Dietrich process provides a guarantee for pharmaceutical and chemical companies that the cleanability of equipment will be optimised and conform to their needs. Furthermore, all requested information (flow rate, pressure) is known in the early stages of the project. De Dietrich offers numerous advantages for clients, from cleanability studies and tests to optimization of tank and unit designs. The company offers an extensive range of high-efficiency CIP equipment, and provides complete engineering solutions for fixed and movable CIP skids and units.

GMP regulations (Part 133.4) and similar (Part 211.67) starts by: Equipment shall be maintained in a clean and orderly manner.

The main concerns of the FDA concerning cleanability are:

• Avoiding contamination of product
• Avoiding cross contamination (by improper cleaning, bad maintenance), and
• "Call back" action of product.

De Dietrich Process Systems, B-803, Sagar Tech Plaza, Sakinaka Junction, Andheri-Kurla Road, Andheri (E), Mumbai 400 072. Tel: 040-27173203. Fax: 91-22-28505731/94. Email: sales@dedietrich.co.in